The Angiopoietin-2/Angiopoietin-1 ratio increases early in burn patients and predicts mortality

Heuberger, Dorothea; Wendel-Garcia, Pedro David; Sazpinar, Onur; Müller, Mattia; Klein, Holger; Kim, Bong-Sung; Andermatt, Rea; Erlebach, Rolf; Schuepbach, Reto A; Buehler, Philipp K; David, Sascha; Hofmaenner, Daniel A

doi:10.5167/uzh-236904

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Heuberger, D., Wendel-Garcia, P. D., Sazpinar, O., Müller, M., Klein, H., Kim, B.-S., Andermatt, R., Erlebach, R., Schuepbach, R. A., Buehler, P. K., David, S., & Hofmaenner, D. A. (2023). The Angiopoietin-2/Angiopoietin-1 ratio increases early in burn patients and predicts mortality. Cytokine, 169, 156266. https://doi.org/10.1016/j.cyto.2023.156266

Abstract

Background: Angiopoietin-2 (Angpt-2) is involved in the pathogenesis of the capillary leak syndrome in sepsis and has been shown to be associated with worse outcomes in diverse critical illnesses. It is however unclear whether Angpt-2 plays a similar role in severely burned patients during the early phase characterized by massive capillary leakage. Our aim was to analyze the Angiopoietin-2/Angiopoietin-1 ratio (Angpt-2/Angpt-1 ratio) over the first two days in critically ill burn patients and examine its association with survival and