Publication: Effect of fluorinated substituents of Zn phthalocyanine: nanoencapsulation and phototoxicity
Effect of fluorinated substituents of Zn phthalocyanine: nanoencapsulation and phototoxicity
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Bruegger, J., Emami, A., Nguyen, C., İşci, Ü., Gjuroski, I., Furrer, J., Trincado, M., Spingler, B., Vermathen, P., Gary-Bobo, M., Dumoulin, F., & Vermathen, M. (2026). Effect of fluorinated substituents of Zn phthalocyanine: nanoencapsulation and phototoxicity. International Journal of Pharmaceutics, 695, 126771. https://doi.org/10.1016/j.ijpharm.2026.126771
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Phthalocyanines are promising photosensitizers for photodynamic therapy due to their advantageous light absorption properties and low dark toxicity. Two non-peripheral substituted phthalocyanines, tetra-ethoxy-Zn-phthalocyanine (CH3Pc) and its fluorinated analogue (CF3Pc), were combined with different nanocarriers, and their photophysical properties and biological activities were studied. Carrier-encapsulation and phthalocyanines’ aggregation state were probed by NMR-, UV–Vis-, and fluorescence spectroscopy. Five different carrier sys
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Bruegger, J., Emami, A., Nguyen, C., İşci, Ü., Gjuroski, I., Furrer, J., Trincado, M., Spingler, B., Vermathen, P., Gary-Bobo, M., Dumoulin, F., & Vermathen, M. (2026). Effect of fluorinated substituents of Zn phthalocyanine: nanoencapsulation and phototoxicity. International Journal of Pharmaceutics, 695, 126771. https://doi.org/10.1016/j.ijpharm.2026.126771
