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Cocaine adulteration with the anthelminthic tetramisole (levamisole/dexamisole): long-term monitoring of its intake by chiral LC-MS/MS analysis of cocaine-positive hair samples

Date

Date

Date
2019
Journal Article
Published version

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Madry, M. M., Kraemer, T., & Baumgartner, M. R. (2019). Cocaine adulteration with the anthelminthic tetramisole (levamisole/dexamisole): long-term monitoring of its intake by chiral LC-MS/MS analysis of cocaine-positive hair samples. Drug Testing and Analysis, 11(3), 472–478. https://doi.org/10.1002/dta.2505

Abstract

Abstract

Abstract

Recent studies indicate that not only the anthelminthic levamisole but also the racemate tetramisole (R-/S-phenyltetraimidazothiazole, PTHIT) was found as adulterant for cocaine. We herein report on the investigation of the prevalence of PTHIT among cocaine-positive hair samples and the discrimination of the presence of its stereoisomers levamisole and dexamisole. Cocaine-positive hair samples were collected in a forensic context in 2015 and mainly 2017 (n=724). Cocaine and PTHIT concentrations have been determined by achiral liquid c

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197 since deposited on 2018-10-02
Acq. date: 2025-11-12

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Creators (Authors)

Journal/Series Title

Journal/Series Title

Journal/Series Title

Volume

Volume

Volume
11

Number

Number

Number
3

Page range/Item number

Page range/Item number

Page range/Item number
472

Page end

Page end

Page end
478

Item Type

Item Type

Item Type
Journal Article

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Keywords

Analytical Chemistry, Spectroscopy, Pharmaceutical Science, Environmental Chemistry

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Language

Language
English

Publication date

Publication date

Publication date
2019-03

Date available

Date available

Date available
2018-10-02

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Publisher

Publisher

ISSN or e-ISSN

ISSN or e-ISSN

ISSN or e-ISSN
1942-7603

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OA Status

OA Status
Closed

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PubMed ID

PubMed ID

Metrics

Views

197 since deposited on 2018-10-02
Acq. date: 2025-11-12

Citations

Citation copied

Madry, M. M., Kraemer, T., & Baumgartner, M. R. (2019). Cocaine adulteration with the anthelminthic tetramisole (levamisole/dexamisole): long-term monitoring of its intake by chiral LC-MS/MS analysis of cocaine-positive hair samples. Drug Testing and Analysis, 11(3), 472–478. https://doi.org/10.1002/dta.2505

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