Publication: A Systems-Level Study Reveals Regulators of Membrane-less Organelles in Human Cells
A Systems-Level Study Reveals Regulators of Membrane-less Organelles in Human Cells
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Berchtold, D., Battich, N., & Pelkmans, L. (2018). A Systems-Level Study Reveals Regulators of Membrane-less Organelles in Human Cells. Molecular Cell, 72, 1035–1049. https://doi.org/10.1016/j.molcel.2018.10.036
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Membrane-less organelles (MLOs) are liquid-like subcellular compartments that form through phase separation of proteins and RNA. While their biophysical properties are increasingly understood, their regulation and the consequences of perturbed MLO states for cell physiology are less clear. To study the regulatory networks, we targeted 1,354 human genes and screened for morphological changes of nucleoli, Cajal bodies, splicing speckles, PML nuclear bodies (PML-NBs), cytoplasmic processing bodies, and stress granules. By multivariate an
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- Berchtold, Doris
- Battich, Nico
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Berchtold, D., Battich, N., & Pelkmans, L. (2018). A Systems-Level Study Reveals Regulators of Membrane-less Organelles in Human Cells. Molecular Cell, 72, 1035–1049. https://doi.org/10.1016/j.molcel.2018.10.036
