Publication: BODIPY-Based Photothermal Agents with Excellent Phototoxic Indices for Cancer Treatment
BODIPY-Based Photothermal Agents with Excellent Phototoxic Indices for Cancer Treatment
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Schneider, L., Kalt, M., Koch, S., Sithamparanathan, S., Villiger, V., Mattiat, J., Kradolfer, F., Slyshkina, E., Luber, S., Bonmarin, M., Maake, C., & Spingler, B. (2023). BODIPY-Based Photothermal Agents with Excellent Phototoxic Indices for Cancer Treatment. Journal of the American Chemical Society, 145(8), 4534–4544. https://doi.org/10.1021/jacs.2c11650
Abstract
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Abstract
Here, we report six novel, easily accessible BODIPY-based agents for cancer treatment. In contrast to established photodynamic therapy (PDT) agents, these BODIPY-based compounds show additional photothermal activity and their cytotoxicity is not dependent on the generation of reactive oxygen species (ROS). The agents show high photocytotoxicity upon irradiation with light and low dark toxicity in different cancer cell lines in 2D culture as well as in 3D multicellular tumor spheroids (MCTSs). The ratio of dark to light toxicity (photo
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Creators (Authors)
- Schneider, Lukas
- Kalt, Martina
- Koch, Samuel
- Sithamparanathan, Shanmugi
- Villiger, Veronika
- Mattiat, Johann
- Kradolfer, Flavia
- Slyshkina, Ekaterina
- Luber, Sandra
- Bonmarin, Mathias
- Maake, Caroline
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Schneider, L., Kalt, M., Koch, S., Sithamparanathan, S., Villiger, V., Mattiat, J., Kradolfer, F., Slyshkina, E., Luber, S., Bonmarin, M., Maake, C., & Spingler, B. (2023). BODIPY-Based Photothermal Agents with Excellent Phototoxic Indices for Cancer Treatment. Journal of the American Chemical Society, 145(8), 4534–4544. https://doi.org/10.1021/jacs.2c11650
