Publication: Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging
Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging
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Giovanoli, S., Notter, T., Richetto, J., Labouesse, M. A., Vuillermot, S., Riva, M. A., & Meyer, U. (2015). Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging. Journal of Neuroinflammation, 12(221), online. https://doi.org/10.1186/s12974-015-0437-y
Abstract
Abstract
Abstract
BACKGROUND: Prenatal exposure to infection and/or inflammation is increasingly recognized to play an important role in neurodevelopmental brain disorders. It has recently been postulated that prenatal immune activation, especially when occurring during late gestational stages, may also induce pathological brain aging via sustained effects on systemic and central inflammation. Here, we tested this hypothesis using an established mouse model of exposure to viral-like immune activation in late pregnancy. METHODS: Pregnant C57BL6/J mice o
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Creators (Authors)
- Giovanoli, Sandra
- Notter, Tina
- Richetto, Juliet
- Labouesse, Marie A
- Vuillermot, Stéphanie
- Riva, Marco A
- Meyer, Urs
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Citations
Giovanoli, S., Notter, T., Richetto, J., Labouesse, M. A., Vuillermot, S., Riva, M. A., & Meyer, U. (2015). Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging. Journal of Neuroinflammation, 12(221), online. https://doi.org/10.1186/s12974-015-0437-y
