Simultaneous quantification of steroid hormones and endocannabinoids (ECs) in human hair using an automated supported liquid extraction (SLE) and LC-MS/MS – Insights into EC baseline values and correlation to steroid concentrations

Voegel, Clarissa Daniela; Baumgartner, Markus R; Kraemer, Thomas; Wüst, Stefan; Binz, Tina M

doi:10.1016/j.talanta.2020.121499

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Voegel, C. D., Baumgartner, M. R., Kraemer, T., Wüst, S., & Binz, T. M. (2021). Simultaneous quantification of steroid hormones and endocannabinoids (ECs) in human hair using an automated supported liquid extraction (SLE) and LC-MS/MS – Insights into EC baseline values and correlation to steroid concentrations. Talanta, 222, 121499. https://doi.org/10.1016/j.talanta.2020.121499

Abstract

Endogenous steroid hormones and endocannabinoids (ECs) are important regulators in the stress response of the human body. For the measurement of chronic stress, hair analysis has been established as method of choice for long-term and retrospective determination of endogenous stress markers. A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of five steroid hormones (cortisone, cortisol, androstenedione, testosterone, progesterone) and four endocannabinoids (anandamide, palmitoylethanola