Publication: Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice
Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice
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Bergamini, G., Mechtersheimer, J., Azzinnari, D., Sigrist, H., Buerge, M., Dallmann, R., Freije, R., Kouraki, A., Opacka-Juffry, J., Seifritz, E., Ferger, B., Suter, T., & Pryce, C. R. (2018). Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice. Neurobiology of Stress, 8, 42–56. https://doi.org/10.1016/j.ynstr.2018.01.004
Abstract
Abstract
Abstract
Psychosocial stress is a major risk factor for depression, stress leads to peripheral and central immune activation, immune activation is associated with blunted dopamine (DA) neural function, DA function underlies reward interest, and reduced reward interest is a core symptom of depression. These states might be inter-independent in a complex causal pathway. Whilst animal-model evidence exists for some specific steps in the pathway, there is currently no animal model in which it has been demonstrated that social stress leads to each
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Creators (Authors)
- Bergamini, Giorgio
- Mechtersheimer, Jonas
- Azzinnari, Damiano
- Sigrist, Hannes
- Buerge, Michaela
- Dallmann, Robert
- Freije, Robert
- Kouraki, Afroditi
- Opacka-Juffry, Jolanta
- Seifritz, Erich
- Ferger, Boris
- Suter, Tobias
- Pryce, Christopher R
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Citations
Bergamini, G., Mechtersheimer, J., Azzinnari, D., Sigrist, H., Buerge, M., Dallmann, R., Freije, R., Kouraki, A., Opacka-Juffry, J., Seifritz, E., Ferger, B., Suter, T., & Pryce, C. R. (2018). Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice. Neurobiology of Stress, 8, 42–56. https://doi.org/10.1016/j.ynstr.2018.01.004
