Publication: Strictly co-isogenic C57BL/6J-Prnp−/−mice: A rigorous resource for prion science
Strictly co-isogenic C57BL/6J-Prnp−/−mice: A rigorous resource for prion science
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Nuvolone, M., Hermann, M., Sorce, S., Russo, G., Tiberi, C., Schwarz, P., Minikel, E., Sanoudou, D., Pelczar, P., & Aguzzi, A. (2016). Strictly co-isogenic C57BL/6J-Prnp−/−mice: A rigorous resource for prion science. Journal of Experimental Medicine, 213(3), 313–327. https://doi.org/10.1084/jem.20151610
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Although its involvement in prion replication and neurotoxicity during transmissible spongiform encephalopathies is undisputed, the physiological role of the cellular prion protein (PrPC) remains enigmatic. A plethora of functions have been ascribed to PrPC based on phenotypes of Prnp−/− mice. However, all currently available Prnp−/− lines were generated in embryonic stem cells from the 129 strain of the laboratory mouse and mostly crossed to non-129 strains. Therefore, Prnp-linked loci polymorphic between 129 and the backcrossing str
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- Nuvolone, Mario
- Hermann, Mario
- Sorce, Silvia
- Russo, Giancarlo
- Tiberi, Cinzia
- Schwarz, Petra
- Minikel, Eric
- Sanoudou, Despina
- Pelczar, Pawel
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Nuvolone, M., Hermann, M., Sorce, S., Russo, G., Tiberi, C., Schwarz, P., Minikel, E., Sanoudou, D., Pelczar, P., & Aguzzi, A. (2016). Strictly co-isogenic C57BL/6J-Prnp−/−mice: A rigorous resource for prion science. Journal of Experimental Medicine, 213(3), 313–327. https://doi.org/10.1084/jem.20151610
