Publication: Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion
Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion
Date
Date
Date
Citations
Baral, P. K., Swayampakula, M., Aguzzi, A., & James, M. N. G. (2018). Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion. FEBS Journal, 285(9), 1701–1714. https://doi.org/10.1111/febs.14438
Abstract
Abstract
Abstract
Conversion of the cellular prion protein PrPC into its pathogenic isoform PrPSc is the hallmark of prion diseases, fatal neurodegenerative diseases affecting many mammalian species including humans. Anti‐prion monoclonal antibodies can arrest the progression of prion diseases by stabilizing the cellular form of the prion protein. Here, we present the crystal structure of the POM6 Fab fragment, in complex with the mouse prion protein (moPrP). The prion epitope of POM6 is in close proximity to the epitope recognized by the purportedly t
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Baral, Pravas Kumar
- Swayampakula, Mridula
- James, Michael N G
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Baral, P. K., Swayampakula, M., Aguzzi, A., & James, M. N. G. (2018). Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion. FEBS Journal, 285(9), 1701–1714. https://doi.org/10.1111/febs.14438
