Publication: TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis
TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis
Date
Date
Date
Citations
Loos, B., Salas-Bastos, A., Nordin, A., Debbache, J., Stierli, S., Cheng, P. F., Rufli, S., Wyss, C., Levesque, M. P., Dummer, R., Wong, W. W.-L., Pascolo, S., Cantù, C., & Sommer, L. (2024). TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis. Cell Death and Disease, 15, 925. https://doi.org/10.1038/s41419-024-07305-1
Abstract
Abstract
Abstract
The TGFβ signaling pathway is known for its pleiotropic functions in a plethora of biological processes. In melanoma, TGFβ signaling promotes invasiveness and metastasis formation. However, its involvement in the response to therapy is controversial. While several studies have linked TGFβ signaling to elevated resistance to targeted therapy in melanoma, separate findings have indicated a favorable treatment response through TGFβ-mediated increase of cell death. We now found that the outcome of TGFβ signaling in the context of targeted
Metrics
Downloads
Views
Citations
Additional indexing
Creators (Authors)
- Loos, Benjamin
- Salas-Bastos, Adrian
- Nordin, Anna
- Debbache, Julien
- Stierli, Salome
- Cheng, Phil F
- Rufli, Stefanie
- Wyss, Conrad
- Levesque, Mitchell P
- Dummer, Reinhard
- Wong, Wendy Wei-Lynn
- Pascolo, Steve
- Cantù, Claudio
- Sommer, Lukas
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Citations
Loos, B., Salas-Bastos, A., Nordin, A., Debbache, J., Stierli, S., Cheng, P. F., Rufli, S., Wyss, C., Levesque, M. P., Dummer, R., Wong, W. W.-L., Pascolo, S., Cantù, C., & Sommer, L. (2024). TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis. Cell Death and Disease, 15, 925. https://doi.org/10.1038/s41419-024-07305-1
