Publication: The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress
The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress
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Piwko, W., Mlejnkova, L. J., Mutreja, K., Ranjha, L., Stafa, D., Smirnov, A., Brodersen, M. M. L., Zellweger, R., Sturzenegger, A., Janscak, P., Lopes, M., Peter, M., & Cejka, P. (2016). The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. The EMBO Journal, 35, 2584–2601. https://doi.org/10.15252/embj.201593132
Abstract
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Abstract
Homologous recombination (HR) is a key pathway that repairs DNA double-strand breaks (DSBs) and helps to restart stalled or collapsed replication forks. How HR supports replication upon genotoxic stress is not understood. Using in vivo and in vitro approaches, we show that the MMS22L-TONSL heterodimer localizes to replication forks under unperturbed conditions and its recruitment is increased during replication stress in human cells. MMS22L-TONSL associates with replication protein A (RPA)-coated ssDNA, and the MMS22L subunit directly
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- Piwko, Wojciech
- Mlejnkova, Lucie J
- Mutreja, Karun
- Ranjha, Lepakshi
- Stafa, Diana
- Smirnov, Alexander
- Brodersen, Mia M L
- Zellweger, Ralph
- Sturzenegger, Andreas
- Janscak, Pavel
- Lopes, Massimo
- Peter, Matthias
- Cejka, Petr
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Piwko, W., Mlejnkova, L. J., Mutreja, K., Ranjha, L., Stafa, D., Smirnov, A., Brodersen, M. M. L., Zellweger, R., Sturzenegger, A., Janscak, P., Lopes, M., Peter, M., & Cejka, P. (2016). The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. The EMBO Journal, 35, 2584–2601. https://doi.org/10.15252/embj.201593132
