High-coverage genome of the Tyrolean Iceman reveals unusually high Anatolian farmer ancestry

Wang, Ke; Prüfer, Kay; Krause-Kyora, Ben; Childebayeva, Ainash; Schuenemann, Verena J; Coia, Valentina; Maixner, Frank; Zink, Albert; Schiffels, Stephan; Krause, Johannes

doi:10.1016/j.xgen.2023.100377

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Wang, K., Prüfer, K., Krause-Kyora, B., Childebayeva, A., Schuenemann, V. J., Coia, V., Maixner, F., Zink, A., Schiffels, S., & Krause, J. (2023). High-coverage genome of the Tyrolean Iceman reveals unusually high Anatolian farmer ancestry. Cell Genomics, 3(9), 100377. https://doi.org/10.1016/j.xgen.2023.100377

Abstract

The Tyrolean Iceman is known as one of the oldest human glacier mummies, directly dated to 3350-3120 calibrated BCE. A previously published low-coverage genome provided novel insights into European prehistory, despite high present-day DNA contamination. Here, we generate a high-coverage genome with low contamination (15.3×) to gain further insights into the genetic history and phenotype of this individual. Contrary to previous studies, we found no detectable Steppe-related ancestry in the Iceman. Instead, he retained the highest Anato