Publication: Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
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Schmid, J. A., Berti, M., Walser, F., Raso, M. C., Schmid, F., Krietsch, J., Stoy, H., Zwicky, K., Ursich, S., Freire, R., Lopes, M., & Penengo, L. (2018). Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase. Molecular Cell, 71(6), 897-910.e8. https://doi.org/10.1016/j.molcel.2018.07.011
Abstract
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Chromatin ubiquitination by the ubiquitin ligase RNF168 is critical to regulate the DNA damage response (DDR). DDR deficiencies lead to cancer-prone syndromes, but whether this reflects DNA repair defects is still elusive. We identified key factors of the RNF168 pathway as essential mediators of efficient DNA replication in unperturbed S phase. We found that loss of RNF168 leads to reduced replication fork progression and to reversed fork accumulation, particularly evident at repetitive sequences stalling replication. Slow fork progre
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- Schmid, Jonas Andreas
- Berti, Matteo
- Walser, Franziska
- Raso, Maria Chiara
- Schmid, Fabian
- Krietsch, Jana
- Stoy, Henriette
- Zwicky, Katharina
- Ursich, Sebastian
- Freire, Raimundo
- Lopes, Massimo
- Penengo, Lorenza
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Schmid, J. A., Berti, M., Walser, F., Raso, M. C., Schmid, F., Krietsch, J., Stoy, H., Zwicky, K., Ursich, S., Freire, R., Lopes, M., & Penengo, L. (2018). Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase. Molecular Cell, 71(6), 897-910.e8. https://doi.org/10.1016/j.molcel.2018.07.011
