Publication: Functionalized Aromatic Sulfones from 1,4‐Benzothiazine‐3‐one‐1,1‐Dioxide: Design, Synthesis, Crystal Structure, and In Silico Evaluation Against SARS‐CoV‐2 Proteins
Functionalized Aromatic Sulfones from 1,4‐Benzothiazine‐3‐one‐1,1‐Dioxide: Design, Synthesis, Crystal Structure, and In Silico Evaluation Against SARS‐CoV‐2 Proteins
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Irrou, E., Ait Elmachkouri, Y., Blacque, O., Kumer, A., MK, K., Oubella, A., Sebbar, N. K., Taha, M. L., & Chagaleti, B. K. (2025). Functionalized Aromatic Sulfones from 1,4‐Benzothiazine‐3‐one‐1,1‐Dioxide: Design, Synthesis, Crystal Structure, and In Silico Evaluation Against SARS‐CoV‐2 Proteins. ChemistrySelect, 10, e03748. https://doi.org/10.1002/slct.202503748
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This study presents a novel, simple, and efficient method for the synthesis of highly functionalized aromatic sulfones (compounds 4 – 9 ) from a 1,4‐benzothiazine‐1,1‐dioxide derivative bearing an ester group at the N ${4}$ position. The reactivity of the compound was explored through nucleophilic addition and substitution reactions with amines, targeting both the C ${3}$
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Irrou, E., Ait Elmachkouri, Y., Blacque, O., Kumer, A., MK, K., Oubella, A., Sebbar, N. K., Taha, M. L., & Chagaleti, B. K. (2025). Functionalized Aromatic Sulfones from 1,4‐Benzothiazine‐3‐one‐1,1‐Dioxide: Design, Synthesis, Crystal Structure, and In Silico Evaluation Against SARS‐CoV‐2 Proteins. ChemistrySelect, 10, e03748. https://doi.org/10.1002/slct.202503748
