Publication: Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia
Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia
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Giovanoli, S., Engler, H., Engler, A., Richetto, J., Feldon, J., Riva, M. A., Schedlowski, M., & Meyer, U. (2016). Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia. Translational Psychiatry, 6(4), e772. https://doi.org/10.1038/tp.2016.38
Abstract
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Abstract
Maternal immune activation can increase the vulnerability of the offspring to develop neuroimmune and behavioral abnormalities in response to stress in puberty. In offspring of immune-challenged mothers, stress-induced inflammatory processes precede the adult onset of multiple behavioral dysfunctions. Here, we explored whether an early anti-inflammatory intervention during peripubertal stress exposure might prevent the subsequent emergence of adult behavioral pathology. We used an environmental two-hit model in mice, in which prenatal
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- Giovanoli, S
- Engler, H
- Engler, A
- Richetto, J
- Feldon, J
- Riva, M A
- Schedlowski, M
- Meyer, Urs
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Giovanoli, S., Engler, H., Engler, A., Richetto, J., Feldon, J., Riva, M. A., Schedlowski, M., & Meyer, U. (2016). Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia. Translational Psychiatry, 6(4), e772. https://doi.org/10.1038/tp.2016.38
