Clinical and histological wound healing patterns of collagen-based substitutes: An experimental randomized controlled trial in standardized palatal defects in humans

Bienz, Stefan P; Gadzo, Naida; Zuercher, Anina N; Wiedemeier, Daniel; Jung, Ronald E; Thoma, Daniel S

doi:10.1111/jcpe.13903

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Bienz, S. P., Gadzo, N., Zuercher, A. N., Wiedemeier, D., Jung, R. E., & Thoma, D. S. (2024). Clinical and histological wound healing patterns of collagen-based substitutes: An experimental randomized controlled trial in standardized palatal defects in humans. Journal of Clinical Periodontology, 51(3), 319–329. https://doi.org/10.1111/jcpe.13903

Abstract

AIM To evaluate the progression of wound healing of standardized palatal defects in groups using three different collagen-based wound dressings and a control group, in terms of wound closure, pain perception and descriptive histology. MATERIALS AND METHODS Twenty participants were enrolled in this experimental study, in whom four palatal defects were created. The defects (6 mm diameter, 3 mm depth) were randomly assigned to one of four treatment modalities: C (control), MG (Mucograft®), MD (mucoderm®) and FG (Fibro-Gide®). Photographs