Publication: Exploring the Roles of Post Translational Modifications in the DNA Replication Fork Dynamics and Protection
Exploring the Roles of Post Translational Modifications in the DNA Replication Fork Dynamics and Protection
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Duzanic, F. (2025). Exploring the Roles of Post Translational Modifications in the DNA Replication Fork Dynamics and Protection. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-278137
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In order to ensure complete and faithful genome duplication, DNA replication forks (RFs) exhibit remarkable plasticity upon encountering diverse obstacles to their progression that lead to a condition of replication stress. Mechanisms employed by the forks under such conditions are collectively referred to as DNA damage tolerance and comprise i) fork reversal ii) translesion DNA synthesis and iii) PrimPol-mediated repriming. While apparently distinct, they are intrinsically and inherently coordinated to facilitate an effective replica
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Duzanic, F. (2025). Exploring the Roles of Post Translational Modifications in the DNA Replication Fork Dynamics and Protection. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-278137
