Publication: SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease
SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease
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Zhu, C., Li, B., Frontzek, K., Liu, Y., & Aguzzi, A. (2019). SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. Journal of Experimental Medicine, jem.20171885. https://doi.org/10.1084/jem.20171885
Abstract
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Abstract
SARM1 (sterile α and HEAT/armadillo motif–containing protein) is a member of the MyD88 (myeloid differentiation primary response gene 88) family, which mediates innate immune responses. Because inactivation of SARM1 prevents various forms of axonal degeneration, we tested whether it might protect against prion-induced neurotoxicity. Instead, we found that SARM1 deficiency exacerbates the progression of prion pathogenesis. This deleterious effect was not due to SARM1-dependent modulation of prion-induced neuroinflammation, since microg
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- Li, Bei
- Frontzek, Karl
- Liu, Yingjun
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Zhu, C., Li, B., Frontzek, K., Liu, Y., & Aguzzi, A. (2019). SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. Journal of Experimental Medicine, jem.20171885. https://doi.org/10.1084/jem.20171885
