Publication: Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo
Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo
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Akhmedov, A., Rozenberg, I., Paneni, F., Camici, G. G., Shi, Y., Doerries, C., Sledzinska, A., Mocharla, P., Breitenstein, A., Lohmann, C., Stein, S., von Lukowicz, T., Kurrer, M. O., Borén, J., Becher, B., Tanner, F. C., Landmesser, U., Matter, C. M., & Lüscher, T. F. (2014). Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo. European Heart Journal, 35(40), 2839–2848. https://doi.org/10.1093/eurheartj/eht532
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Abstract
AIMS: Lectin-like oxLDL receptor-1 (LOX-1) mediates the uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells and macrophages. However, the different atherogenic potential of LOX-1-mediated endothelial and macrophage oxLDL uptake remains unclear. The present study was designed to investigate the in vivo role of endothelial LOX-1 in atherogenesis. METHODS AND RESULTS: Endothelial-specific LOX-1 transgenic mice were generated using the Tie2 promoter (LOX-1TG). Oxidized low-density lipoprotein uptake was enhanced in cul
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- Akhmedov, Alexander
- Rozenberg, Izabela
- Paneni, Francesco
- Camici, Giovanni G
- Shi, Yi
- Doerries, Carola
- Sledzinska, Anna
- Mocharla, Pavani
- Breitenstein, Alexander
- Lohmann, Christine
- Stein, Sokrates
- von Lukowicz, Tobias
- Kurrer, Michael O
- Borén, Jan
- Becher, Burkhard
- Tanner, Felix C
- Landmesser, Ulf
- Matter, Christian M
- Lüscher, Thomas F
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Akhmedov, A., Rozenberg, I., Paneni, F., Camici, G. G., Shi, Y., Doerries, C., Sledzinska, A., Mocharla, P., Breitenstein, A., Lohmann, C., Stein, S., von Lukowicz, T., Kurrer, M. O., Borén, J., Becher, B., Tanner, F. C., Landmesser, U., Matter, C. M., & Lüscher, T. F. (2014). Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo. European Heart Journal, 35(40), 2839–2848. https://doi.org/10.1093/eurheartj/eht532
