Publication: RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis
RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis
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Zhao, X., Bramsiepe, J., Van Durme, M., Komaki, S., Prusicki, M. A., Maruyama, D., Forner, J., Medzihradszky, A., Wijnker, E., Harashima, H., Lu, Y., Schmidt, A., Guthörl, D., Logroño, R. S., Guan, Y., Pochon, G., Grossniklaus, U., Laux, T., Higashiyama, T., … Schnittger, A. (2017). RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis. Science, 356, 6336. https://doi.org/10.1126/science.aaf6532
Abstract
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Abstract
To produce seeds, flowering plants need to specify somatic cells to undergo meiosis. Here, we reveal a regulatory cascade that controls the entry into meiosis starting with a group of redundantly acting cyclin-dependent kinase (CDK) inhibitors of the KIP-RELATED PROTEIN (KRP) class. KRPs function by restricting CDKA;1-dependent inactivation of the Arabidopsis Retinoblastoma homolog RBR1. In rbr1 and krp triple mutants, designated meiocytes undergo several mitotic divisions, resulting in the formation of supernumerary meiocytes that gi
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Creators (Authors)
- Zhao, Xin’Ai
- Bramsiepe, Jonathan
- Van Durme, Matthias
- Komaki, Shinichiro
- Prusicki, Maria Ada
- Maruyama, Daisuke
- Forner, Joachim
- Medzihradszky, Anna
- Wijnker, Erik
- Harashima, Hirofumi
- Lu, You
- Schmidt, Anja
- Guthörl, Daniela
- Logroño, Rosa Sahún
- Guan, Yonsheng
- Pochon, Gaetan
- Grossniklaus, Ueli
- Laux, Thomas
- Higashiyama, Tetsuya
- Lohmann, Jan U
- Nowack, Moritz K
- Schnittger, Arp
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Zhao, X., Bramsiepe, J., Van Durme, M., Komaki, S., Prusicki, M. A., Maruyama, D., Forner, J., Medzihradszky, A., Wijnker, E., Harashima, H., Lu, Y., Schmidt, A., Guthörl, D., Logroño, R. S., Guan, Y., Pochon, G., Grossniklaus, U., Laux, T., Higashiyama, T., … Schnittger, A. (2017). RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis. Science, 356, 6336. https://doi.org/10.1126/science.aaf6532
