Publication: Verification of the fetal valproate syndrome phenotype
Verification of the fetal valproate syndrome phenotype
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Ardinger, H. H., Atkin, J. F., Blackston, R. D., Elsas, L. J., Clarren, S. K., Livingstone, S., Flannery, D. B., Pellock, J. M., Harrod, M. J., Lammer, E. J., Majewski, F., Schinzel, A., Toriello, H. V., Hanson, J. W., Optiz, J. M., & Reynolds, J. F. (1988). Verification of the fetal valproate syndrome phenotype. American Journal of Medical Genetics, 29(1), 171–185. https://doi.org/10.1002/ajmg.1320290123
Abstract
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We have evaluated 19 children who were exposed to valproic acid (VPA) in utero to look for manifestations of a fetal valproate syndrome (FVS), as proposed by Di Liberti et al. [1984]. We found no consistent alterations of pre- or postnatal growth with exposure to VPA monotherapy. Postnatal growth deficiency and microcephaly were present however, in two thirds of children exposed to VPA in combination with other anticonvulsants. Developmental delay or neurologic abnormality was found in 71% of those exposed to VPA monotherapy, and in 9
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- Ardinger, Holly H
- Atkin, Joan F
- Blackston, R Dwain
- Elsas, Louis J
- Clarren, Sterling K
- Livingstone, Susan
- Flannery, David B
- Pellock, John M
- Harrod, Mary Jo
- Lammer, Edward J
- Majewski, Frank
- Schinzel, Albert
- Toriello, Helga V
- Hanson, James W
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Ardinger, H. H., Atkin, J. F., Blackston, R. D., Elsas, L. J., Clarren, S. K., Livingstone, S., Flannery, D. B., Pellock, J. M., Harrod, M. J., Lammer, E. J., Majewski, F., Schinzel, A., Toriello, H. V., Hanson, J. W., Optiz, J. M., & Reynolds, J. F. (1988). Verification of the fetal valproate syndrome phenotype. American Journal of Medical Genetics, 29(1), 171–185. https://doi.org/10.1002/ajmg.1320290123
