Publication: Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis
Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis
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Karpstein, T., Zhong, S., Keller, S., Späne, P., Häberli, C., Panic, G., Blacque, O., Cariou, K., Gasser, G., & Keiser, J. (2025). Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis. ChemMedChem, 20(23), e202500603. https://doi.org/10.1002/cmdc.202500603
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Schistosomiasis affects hundreds of millions of people worldwide, yet its chemotherapeutic treatment is based on the only drug available‐praziquantel (PZQ). The development of alternative treatment options is urgent, not only due to the threat of drug resistance, but also because the drawbacks of PZQ, such as its inactivity against juvenile stages, contribute to its incomplete cure rates, thus requiring repeated treatment. This study presents the design, synthesis, characterization, and biological evaluation of 10 novel organometallic
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Karpstein, T., Zhong, S., Keller, S., Späne, P., Häberli, C., Panic, G., Blacque, O., Cariou, K., Gasser, G., & Keiser, J. (2025). Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis. ChemMedChem, 20(23), e202500603. https://doi.org/10.1002/cmdc.202500603
