Publication: Modulation of the chromatin phosphoproteome by the Haspin protein kinase
Modulation of the chromatin phosphoproteome by the Haspin protein kinase
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Maiolica, A., de Medina-Redondo, M., Schoof, E. M., Chaikuad, A., Villa, F., Gatti, M., et al, & Penengo, L. (2014). Modulation of the chromatin phosphoproteome by the Haspin protein kinase. Molecular & Cellular Proteomics, 13, 1724–1740. https://doi.org/10.1074/mcp.M113.034819
Abstract
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Recent discoveries have highlighted the importance of Haspin kinase activity for the correct positioning of the kinase Aurora B at the centromere. Haspin phosphorylates Thr(3) of the histone H3 (H3), which provides a signal for Aurora B to localize to the centromere of mitotic chromosomes. To date, histone H3 is the only confirmed Haspin substrate. We used a combination of biochemical, pharmacological, and mass spectrometric approaches to study the consequences of Haspin inhibition in mitotic cells. We quantified 3964 phosphorylation
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- Maiolica, Alessio
- de Medina-Redondo, Maria
- Schoof, Erwin M
- Chaikuad, Apirat
- Villa, Fabrizio
- Gatti, Marco
- Penengo, Lorenza
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Maiolica, A., de Medina-Redondo, M., Schoof, E. M., Chaikuad, A., Villa, F., Gatti, M., et al, & Penengo, L. (2014). Modulation of the chromatin phosphoproteome by the Haspin protein kinase. Molecular & Cellular Proteomics, 13, 1724–1740. https://doi.org/10.1074/mcp.M113.034819
