Publication: A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects
A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects
Date
Date
Date
Citations
Küng, C. J., Daryadel, A., Fuente, R., Haykir, B., de Angelis, M. H., Hernando, N., Rubio-Aliaga, I., & Wagner, C. A. (2024). A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects. Pflügers Archiv : European Journal of Physiology, 476(5), 833–845. https://doi.org/10.1007/s00424-024-02927-y
Abstract
Abstract
Abstract
The Calcium-sensing receptor (CaSR) senses extracellular calcium, regulates parathyroid hormone (PTH) secretion, and has additional functions in various organs related to systemic and local calcium and mineral homeostasis. Familial hypocalciuric hypercalcemia type I (FHH1) is caused by heterozygous loss-of-function mutations in the CaSR gene, and is characterized by the combination of hypercalcemia, hypocalciuria, normal to elevated PTH, and facultatively hypermagnesemia and mild bone mineralization defects. To date, only heterozygous
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
Journal/Series Title
Journal/Series Title
Journal/Series Title
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Publisher DOI
Metrics
Downloads
Views
Citations
Küng, C. J., Daryadel, A., Fuente, R., Haykir, B., de Angelis, M. H., Hernando, N., Rubio-Aliaga, I., & Wagner, C. A. (2024). A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects. Pflügers Archiv : European Journal of Physiology, 476(5), 833–845. https://doi.org/10.1007/s00424-024-02927-y
