Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response

Squarzanti, Diletta Francesca; Sorrentino, Rita; Landini, Manuela Miriam; Chiesa, Andrea; Pinato, Sabrina; Rocchio, Francesca; Mattii, Martina; Penengo, Lorenza; Azzimonti, Barbara

doi:10.1186/s12985-018-1086-4

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Squarzanti, D. F., Sorrentino, R., Landini, M. M., Chiesa, A., Pinato, S., Rocchio, F., Mattii, M., Penengo, L., & Azzimonti, B. (2018). Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response. Virology Journal, 15(1), 176. https://doi.org/10.1186/s12985-018-1086-4

Abstract

BACKGROUND Despite vaccination and screening measures, anogenital cancer, mainly promoted by HPV16 oncoproteins, still represents the fourth tumor and the second cause of death among women. Cell replication fidelity is the result of the host DNA damage response (DDR). Unlike many DNA viruses that promote their life cycle through the DDR inactivation, HR-HPVs encourage cells proliferation despite the DDR turned on. Why and how it occurs has been only partially elucidated. During HPV16 infection, E6 links and degrades p53 via the bindin