Publication: Skin Cancer Induction by the Antimycotic Drug Voriconazole Is Caused by Impaired DNA Damage Detection Due to Chromatin Compaction
Skin Cancer Induction by the Antimycotic Drug Voriconazole Is Caused by Impaired DNA Damage Detection Due to Chromatin Compaction
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Giovannini, S., Weibel, L., Schittek, B., Sinnberg, T., Schaller, M., Lemberg, C., Fehrenbacher, B., Biesemeier, A., Nordin, R., Ivanova, I., Kurz, B., Svilenska, T., Berger, C., Bourquin, J.-P., Kulik, A., Fassihi, H., Lehmann, A., Sarkany, R., Kobert, N., … Berneburg, M. (2024). Skin Cancer Induction by the Antimycotic Drug Voriconazole Is Caused by Impaired DNA Damage Detection Due to Chromatin Compaction. Journal of Investigative Dermatology, 144(11), 2465–2476. https://doi.org/10.1016/j.jid.2024.03.050
Abstract
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Phototoxicity and skin cancer are severe adverse effects of the anti-fungal drug voriconazole (VOR). These adverse effects resemble those seen in xeroderma pigmentosum, caused by defective DNA nucleotide excision repair (NER), and we show that VOR decreases NER capacity. We show that VOR treatment does not perturb the expression of NER, or other DNA damage-related genes, but that VOR localizes to heterochromatin, in complexes containing histone acetyltransferase general control of amino-acid synthesis 5-like 2. Impairment of general c
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Creators (Authors)
- Giovannini, Sara
- Weibel, Lisa
- Schittek, Birgit
- Sinnberg, Tobias
- Schaller, Martin
- Lemberg, Christina
- Fehrenbacher, Birgit
- Biesemeier, Antje
- Nordin, Renate
- Ivanova, Irina
- Kurz, Bernadett
- Svilenska, Teodora
- Bourquin, Jean-Pierre
- Kulik, Andreas
- Fassihi, Hiva
- Lehmann, Alan
- Sarkany, Robert
- Kobert, Nikita
- van Toorn, Marvin
- Marteijn, Jurgen A
- French, Lars E
- Rocken, Martin
- Vermeulen, Wim
- Kamenisch, York
- Berneburg, Mark
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Giovannini, S., Weibel, L., Schittek, B., Sinnberg, T., Schaller, M., Lemberg, C., Fehrenbacher, B., Biesemeier, A., Nordin, R., Ivanova, I., Kurz, B., Svilenska, T., Berger, C., Bourquin, J.-P., Kulik, A., Fassihi, H., Lehmann, A., Sarkany, R., Kobert, N., … Berneburg, M. (2024). Skin Cancer Induction by the Antimycotic Drug Voriconazole Is Caused by Impaired DNA Damage Detection Due to Chromatin Compaction. Journal of Investigative Dermatology, 144(11), 2465–2476. https://doi.org/10.1016/j.jid.2024.03.050
