Publication: Systematic identification of structure-specific protein–protein interactions
Systematic identification of structure-specific protein–protein interactions
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Holfeld, A., Schuster, D., Sesterhenn, F., Gillingham, A. K., Stalder, P., Haenseler, W., Barrio-Hernandez, I., Ghosh, D., Vowles, J., Cowley, S. A., Nagel, L., Khanppnavar, B., Serdiuk, T., Beltrao, P., Korkhov, V. M., Munro, S., Riek, R., de Souza, N., & Picotti, P. (2024). Systematic identification of structure-specific protein–protein interactions. Molecular Systems Biology, 20(6), 651–675. https://doi.org/10.1038/s44320-024-00037-6
Abstract
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Abstract
The physical interactome of a protein can be altered upon perturbation, modulating cell physiology and contributing to disease. Identifying interactome differences of normal and disease states of proteins could help understand disease mechanisms, but current methods do not pinpoint structure-specific PPIs and interaction interfaces proteome-wide. We used limited proteolysis–mass spectrometry (LiP–MS) to screen for structure-specific PPIs by probing for protease susceptibility changes of proteins in cellular extracts upon treatment wit
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- Holfeld, Aleš
- Schuster, Dina
- Sesterhenn, Fabian
- Gillingham, Alison K
- Stalder, Patrick
- Barrio-Hernandez, Inigo
- Ghosh, Dhiman
- Vowles, Jane
- Cowley, Sally A
- Nagel, Luise
- Khanppnavar, Basavraj
- Serdiuk, Tetiana
- Beltrao, Pedro
- Korkhov, Volodymyr M
- Munro, Sean
- Riek, Roland
- de Souza, Natalie
- Picotti, Paola
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Holfeld, A., Schuster, D., Sesterhenn, F., Gillingham, A. K., Stalder, P., Haenseler, W., Barrio-Hernandez, I., Ghosh, D., Vowles, J., Cowley, S. A., Nagel, L., Khanppnavar, B., Serdiuk, T., Beltrao, P., Korkhov, V. M., Munro, S., Riek, R., de Souza, N., & Picotti, P. (2024). Systematic identification of structure-specific protein–protein interactions. Molecular Systems Biology, 20(6), 651–675. https://doi.org/10.1038/s44320-024-00037-6
