Publication: Reactivation of embryonic genetic programs in tissue regeneration and disease
Reactivation of embryonic genetic programs in tissue regeneration and disease
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Fazilaty, H., & Basler, K. (2023). Reactivation of embryonic genetic programs in tissue regeneration and disease. Nature Genetics, 55(11), 1792–1806. https://doi.org/10.1038/s41588-023-01526-4
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Embryonic genetic programs are reactivated in response to various types of tissue damage, providing cell plasticity for tissue regeneration or disease progression. In acute conditions, these programs remedy the damage and then halt to allow a return to homeostasis. In chronic situations, including inflammatory diseases, fibrosis and cancer, prolonged activation of embryonic programs leads to disease progression and tissue deterioration. Induction of progenitor identity and cell plasticity, for example, epithelial-mesenchymal plasticit
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- Fazilaty, Hassan
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Fazilaty, H., & Basler, K. (2023). Reactivation of embryonic genetic programs in tissue regeneration and disease. Nature Genetics, 55(11), 1792–1806. https://doi.org/10.1038/s41588-023-01526-4
