Publication: Photostable Platinated Bacteriochlorins as Potent Photodynamic Agents
Photostable Platinated Bacteriochlorins as Potent Photodynamic Agents
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Le, N. A., Babu, V., Kalt, M., Schneider, L., Schumer, F., & Spingler, B. (2021). Photostable Platinated Bacteriochlorins as Potent Photodynamic Agents. Journal of Medicinal Chemistry, 64(10), 6792–6801. https://doi.org/10.1021/acs.jmedchem.1c00052
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Photodynamic therapy (PDT) is used to treat various cancerous diseases. Recently, we have demonstrated that platinated pyridyl-substituted porphyrins are potent agents for PDT with very high phototoxicity (IC50 down to 17 nM) and excellent phototoxic indices of higher than 5800 (p.i. = IC50(dark)/IC50(light)) [Rubbiani, R. et al., Chem. Commun. 2020, 56, 14373]. However, the absorption of porphyrins is not ideal for the treatment of larger tumors because they essentially do not absorb light between 650 and 850 nm. Herein, we report st
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- Le, Ngoc An
- Babu, Vipin
- Kalt, Martina
- Schneider, Lukas
- Schumer, Frank
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Le, N. A., Babu, V., Kalt, M., Schneider, L., Schumer, F., & Spingler, B. (2021). Photostable Platinated Bacteriochlorins as Potent Photodynamic Agents. Journal of Medicinal Chemistry, 64(10), 6792–6801. https://doi.org/10.1021/acs.jmedchem.1c00052
