Publication: ERK1/2-Dependent Phosphorylation of GABA${B1}$(S867/T872), Controlled by CaMKIIβ, Is Required for GABA${B}$ Receptor Degradation under Physiological and Pathological Conditions
ERK1/2-Dependent Phosphorylation of GABA${B1}$(S867/T872), Controlled by CaMKIIβ, Is Required for GABA${B}$ Receptor Degradation under Physiological and Pathological Conditions
Date
Date
Date
Citations
Bhat, M. A., Grampp, T., & Benke, D. (2023). ERK1/2-Dependent Phosphorylation of GABA${B1}$(S867/T872), Controlled by CaMKIIβ, Is Required for GABA${B}$ Receptor Degradation under Physiological and Pathological Conditions. International Journal of Molecular Sciences, 24(17), 13436. https://doi.org/10.3390/ijms241713436
Abstract
Abstract
Abstract
GABA${B}$ receptor-mediated inhibition is indispensable for maintaining a healthy neuronal excitation/inhibition balance. Many neurological diseases are associated with a disturbed excitation/inhibition balance and downregulation of GABA${B}$ receptors due to enhanced sorting of the receptors to lysosomal degradation. A key event triggering the downregulation of the receptors is the phosphorylation of S867 in the GABA${B1}$ subunit mediated by CaMKIIβ. Interestingly, close to S867 in GABA${B1}$
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Bhat, Musadiq A
- Grampp, Thomas
- Benke, Dietmar
Journal/Series Title
Journal/Series Title
Journal/Series Title
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Other Identification Number
Other Identification Number
Other Identification Number
Metrics
Downloads
Views
Citations
Bhat, M. A., Grampp, T., & Benke, D. (2023). ERK1/2-Dependent Phosphorylation of GABA${B1}$(S867/T872), Controlled by CaMKIIβ, Is Required for GABA${B}$ Receptor Degradation under Physiological and Pathological Conditions. International Journal of Molecular Sciences, 24(17), 13436. https://doi.org/10.3390/ijms241713436
