Publication: Ex vivo expanded haematopoietic progenitor cells improve dermal wound healing by paracrine mechanisms
Ex vivo expanded haematopoietic progenitor cells improve dermal wound healing by paracrine mechanisms
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Templin, C., Grote, K., Schledzewski, K., Ghadri, J. R., Schnabel, S., Napp, L. C., Schieffer, B., Kurzen, H., Goerdt, S., Landmesser, U., Koenen, W., & Faulhaber, J. (2009). Ex vivo expanded haematopoietic progenitor cells improve dermal wound healing by paracrine mechanisms. Experimental Dermatology, 18(5), 445–453. https://doi.org/10.1111/j.1600-0625.2008.00809.x
Abstract
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Abstract
BACKGROUND: Although dermal wounds are common, treatment remains limited and largely ineffective. Recent studies suggest that therapeutic application of progenitor cells is useful for tissue regeneration. OBJECTIVE: We here investigated the effects exerted by the recently characterized immortalized haematopoietic progenitor cell line DKmix and their conditioned medium in a murine wound healing model. METHODS AND RESULTS: Injection of both DKmix cells and their conditioned medium accelerated wound repair between days 3 and 10 compared
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- Templin, C
- Grote, K
- Schledzewski, K
- Ghadri, J R
- Schnabel, S
- Napp, L C
- Schieffer, B
- Kurzen, H
- Goerdt, S
- Landmesser, U
- Koenen, W
- Faulhaber, J
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Templin, C., Grote, K., Schledzewski, K., Ghadri, J. R., Schnabel, S., Napp, L. C., Schieffer, B., Kurzen, H., Goerdt, S., Landmesser, U., Koenen, W., & Faulhaber, J. (2009). Ex vivo expanded haematopoietic progenitor cells improve dermal wound healing by paracrine mechanisms. Experimental Dermatology, 18(5), 445–453. https://doi.org/10.1111/j.1600-0625.2008.00809.x
