Publication: LPS induces limited activation of hypoxia-inducible factor-1α in macrophages
LPS induces limited activation of hypoxia-inducible factor-1α in macrophages
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Isagawa, T., Morioka, M. S., Semba, H., Sawaki, D., Sato, T., Wake, M., Sugimoto, H., Sato, S., Ono, K., Ariunbold, C.-E., Pham, T. T., Tanaka, R., Kawakami, T., Ito, M., Minatsuki, S., Higashikuni, Y., Bono, H., Harada, H., Asagiri, M., … Takeda, N. (2025). LPS induces limited activation of hypoxia-inducible factor-1α in macrophages. Journal of Biological Chemistry, 301(12), 110932. https://doi.org/10.1016/j.jbc.2025.110932
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Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in cellular and tissue adaptation to low oxygen conditions. Although inflammatory stimuli such as lipopolysaccharide (LPS) also increase HIF-1α levels under normoxia, its transcriptional activity and regulatory mechanisms in this context remain unclear. To address this, we performed chromatin immunoprecipitation sequencing and transcriptome analyses in murine macrophages stimulated with either LPS or hypoxia. Both stimuli stabilized HIF-1α protein but via distinct mechanisms: h
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Isagawa, T., Morioka, M. S., Semba, H., Sawaki, D., Sato, T., Wake, M., Sugimoto, H., Sato, S., Ono, K., Ariunbold, C.-E., Pham, T. T., Tanaka, R., Kawakami, T., Ito, M., Minatsuki, S., Higashikuni, Y., Bono, H., Harada, H., Asagiri, M., … Takeda, N. (2025). LPS induces limited activation of hypoxia-inducible factor-1α in macrophages. Journal of Biological Chemistry, 301(12), 110932. https://doi.org/10.1016/j.jbc.2025.110932
