Sequential effects of propofol on functional brain activation induced by auditory language processing: an event-related functional magnetic resonance imaging study.

Heinke, W; Fiebach, C J; Schwarzbauer, C; Meyer, Martin; Olthoff, D; Alter, K

doi:10.1093/bja/aeh133

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Heinke, W., Fiebach, C. J., Schwarzbauer, C., Meyer, M., Olthoff, D., & Alter, K. (2004). Sequential effects of propofol on functional brain activation induced by auditory language processing: an event-related functional magnetic resonance imaging study. British Journal of Anaesthesia, 92(5), 641–650. https://doi.org/10.1093/bja/aeh133

Abstract

BACKGROUND: We have investigated the effect of propofol on language processing using event-related functional magnetic resonance imaging (MRI).

METHODS: Twelve healthy male volunteers underwent MRI scanning at a magnetic field strength of 3 Tesla while performing an auditory language processing task. Functional images were acquired from the perisylvian cortical regions that are associated with auditory and language processing. The experiment consisted of three blocks: awake state (block 1), induction of anaesthesia with 3 mg kg(-1) p