Publication: MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections
MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections
Date
Date
Date
Citations
Roehrig, C., Huemer, M., Lorgé, D., Arn, F., Heinrich, N., Selvakumar, L., Gasser, L., Hauswirth, P., Chang, C.-C., Schweizer, T. A., Eichenseher, F., Lehmann, S., Zinkernagel, A. S., & Schmelcher, M. (2024). MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections. MBio, 15, e0254023. https://doi.org/10.1128/mbio.02540-23
Abstract
Abstract
Abstract
One of the most pressing challenges of our era is the rising occurrence of bacteria that are resistant to antibiotics. Staphylococci are prominent pathogens in humans, which have developed multiple strategies to evade the effects of antibiotics. Infections caused by these bacteria have resulted in a high burden on the health care system and a significant loss of lives. In this study, we have successfully engineered lytic enzymes that exhibit an extraordinary ability to eradicate staphylococci. Our findings substantiate the importance
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Roehrig, Christian
- Huemer, Markus
- Lorgé, Dominique
- Arn, Fabienne
- Heinrich, Nadine
- Selvakumar, Lavanja
- Gasser, Lynn
- Hauswirth, Patrick
- Chang, Chun-Chi
- Schweizer, Tiziano A
- Eichenseher, Fritz
- Lehmann, Steffi
- Zinkernagel, Annelies S
- Schmelcher, Mathias
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Roehrig, C., Huemer, M., Lorgé, D., Arn, F., Heinrich, N., Selvakumar, L., Gasser, L., Hauswirth, P., Chang, C.-C., Schweizer, T. A., Eichenseher, F., Lehmann, S., Zinkernagel, A. S., & Schmelcher, M. (2024). MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections. MBio, 15, e0254023. https://doi.org/10.1128/mbio.02540-23
