Neurophysiological signature of gamma-hydroxybutyrate augmented sleep in healthy male volunteers may reflect biomimetic sleep enhancement: A randomized controlled trial

Dornbierer, Dario A; Baur, Diego M; Stucky, Benjamin; Quednow, Boris B; Kraemer, Thomas; Seifritz, E; Bosch, O G; Landolt, Hans-Peter

doi:10.1038/s41386-019-0382-z

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Dornbierer, D. A., Baur, D. M., Stucky, B., Quednow, B. B., Kraemer, T., Seifritz, E., Bosch, O. G., & Landolt, H.-P. (2019). Neurophysiological signature of gamma-hydroxybutyrate augmented sleep in healthy male volunteers may reflect biomimetic sleep enhancement: A randomized controlled trial. Neuropsychopharmacology, 44(11), 1985–1993. https://doi.org/10.1038/s41386-019-0382-z

Abstract

Gamma-hydroxybutyrate (GHB) is an endogenous GHB/GABAB receptor agonist, which has demonstrated potency in consolidating sleep and reducing excessive daytime sleepiness in narcolepsy. Little is known whether GHB's efficacy reflects the promotion of physiological sleep mechanisms and no study has investigated its sleep consolidating effects under low sleep pressure. GHB (50 mg/kg p.o.) and placebo were administered in 20 young male volunteers at 2:30 a.m., the time when GHB is typically given in narcolepsy, in a randomized, double-blin