Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage

Voikar, Vootele; Krackow, Sven; Lipp, Hans-Peter; Rau, Anton; Colacicco, Giovanni; Wolfer, David P

doi:10.1016/j.bbr.2017.08.048

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Voikar, V., Krackow, S., Lipp, H.-P., Rau, A., Colacicco, G., & Wolfer, D. P. (2018). Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage. Behavioural Brain Research, 352, 8–22. https://doi.org/10.1016/j.bbr.2017.08.048

Abstract

To evaluate permanent effects of hippocampal and prefrontal cortex lesion on spatial tasks, lesioned and sham-operated female C57BL/6 mice were exposed to a series of conditioning schemes in IntelliCages housing 8–10 transponder-tagged mice from each treatment group. Sequential testing started at 51–172 days after bilateral lesions and lasted for 154 and 218 days in two batches of mice, respectively. Spontaneous undisturbed behavioral patterns clearly separated the three groups, hippocampals being characterized by more erratic hyperac