Publication: Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans
Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans
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Jongsma, E., Goyala, A., Mateos, J. M., & Ewald, C. Y. (2023). Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans. ELife, 12, e83465. https://doi.org/10.7554/elife.83465
Abstract
Abstract
Abstract
The amyloid beta (Aβ) plaques found in Alzheimer’s disease (AD) patients’ brains contain collagens and are embedded extracellularly. Several collagens have been proposed to influence Aβ aggregate formation, yet their role in clearance is unknown. To investigate the potential role of collagens in forming and clearance of extracellular aggregates in vivo, we created a transgenic Caenorhabditis elegans strain that expresses and secretes human Aβ$_{1-42}$. This secreted Aβ forms aggregates in two distinct places within the extracellular m
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- Jongsma, Elisabeth
- Goyala, Anita
- Ewald, Collin Yvès
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Jongsma, E., Goyala, A., Mateos, J. M., & Ewald, C. Y. (2023). Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans. ELife, 12, e83465. https://doi.org/10.7554/elife.83465
