Remarkably divergent regions punctuate the genome assembly of the Caenorhabditis elegans Hawaiian strain CB4856

Thompson, Owen A; Snoek, L Basten; Nijveen, Harm; Sterken, Mark G; Volkers, Rita J M; Brenchley, Rachel; Van't Hof, Arjen; Bevers, Roel P J; Cossins, Andrew R; Yanai, Itai; Hajnal, Alex; Schmid, Tobias; Perkins, Jaryn D; Spencer, David; Kruglyak, Leonid; Andersen, Erik C; Moerman, Donald G; Hillier, LaDeana W; Kammenga, Jan E; Waterston, Robert H

doi:10.5167/uzh-115405

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Thompson, O. A., Snoek, L. B., Nijveen, H., Sterken, M. G., Volkers, R. J. M., Brenchley, R., Van’t Hof, A., Bevers, R. P. J., Cossins, A. R., Yanai, I., Hajnal, A., Schmid, T., Perkins, J. D., Spencer, D., Kruglyak, L., Andersen, E. C., Moerman, D. G., Hillier, L. W., Kammenga, J. E., & Waterston, R. H. (2015). Remarkably divergent regions punctuate the genome assembly of the Caenorhabditis elegans Hawaiian strain CB4856. Genetics, 200(3), 975–989. https://doi.org/10.1534/genetics.115.175950

Abstract

The Hawaiian strain (CB4856) of Caenorhabditis elegans is one of the most divergent from the canonical laboratory strain N2 and has been widely used in developmental, population, and evolutionary studies. To enhance the utility of the strain, we have generated a draft sequence of the CB4856 genome, exploiting a variety of resources and strategies. When compared against the N2 reference, the CB4856 genome has 327,050 single nucleotide variants (SNVs) and 79,529 insertion-deletion events that result in a total of 3.3 Mb of N2 sequence m