Publication: Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
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Jungfer, K., Sigg, A., & Jinek, M. (2024). Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Research, 52(1), 462–473. https://doi.org/10.1093/nar/gkad1102
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Abstract
Type III CRISPR-Cas systems provide adaptive immunity against foreign mobile genetic elements through RNA-guided interference. Sequence-specific recognition of RNA targets by the type III effector complex triggers the generation of cyclic oligoadenylate (cOA) second messengers that activate ancillary effector proteins, thus reinforcing the host immune response. The ancillary nuclease Can2 is activated by cyclic tetra-AMP (cA4); however, the mechanisms underlying cA4-mediated activation and substrate selectivity remain elusive. Here we
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- Jungfer, Kenny
- Sigg, Annina
- Jinek, Martin
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Jungfer, K., Sigg, A., & Jinek, M. (2024). Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Research, 52(1), 462–473. https://doi.org/10.1093/nar/gkad1102
