Publication: Biochemistry and genetics are coming together to improve our understanding of genotype to phenotype relationships
Biochemistry and genetics are coming together to improve our understanding of genotype to phenotype relationships
Date
Date
Date
Citations
Notbohm, J., & Perica, T. (2024). Biochemistry and genetics are coming together to improve our understanding of genotype to phenotype relationships. Current Opinion in Structural Biology, 89, 102952. https://doi.org/10.1016/j.sbi.2024.102952
Abstract
Abstract
Abstract
Since genome sequencing became accessible, determining how specific differences in genotypes lead to complex phenotypes such as disease has become one of the key goals in biomedicine. Predicting effects of sequence variants on cellular or organismal phenotype faces several challenges. First, variants simultaneously affect multiple protein properties and predicting their combined effect is complex. Second, effects of changes in a single protein propagate through the cellular network, which we only partially understand. In this review,
Metrics
Downloads
Views
Citations
Additional indexing
Creators (Authors)
- Notbohm, Judith
- Perica, Tina
Volume
Volume
Volume
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Citations
Notbohm, J., & Perica, T. (2024). Biochemistry and genetics are coming together to improve our understanding of genotype to phenotype relationships. Current Opinion in Structural Biology, 89, 102952. https://doi.org/10.1016/j.sbi.2024.102952
