Publication: Notch Signaling Pathway in Tooth Shape Variations throughout Evolution
Notch Signaling Pathway in Tooth Shape Variations throughout Evolution
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Mitsiadis, T. A., Pagella, P., Gomes Rodrigues, H., Tsouknidas, A., Ramenzoni, L. L., Radtke, F., Mehl, A., & Viriot, L. (2023). Notch Signaling Pathway in Tooth Shape Variations throughout Evolution. Cells, 12(5), 761. https://doi.org/10.3390/cells12050761
Abstract
Abstract
Abstract
Evolutionary changes in vertebrates are linked to genetic alterations that often affect tooth crown shape, which is a criterion of speciation events. The Notch pathway is highly conserved between species and controls morphogenetic processes in most developing organs, including teeth. Epithelial loss of the Notch-ligand Jagged1 in developing mouse molars affects the location, size and interconnections of their cusps that lead to minor tooth crown shape modifications convergent to those observed along Muridae evolution. RNA sequencing a
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- Mitsiadis, Thimios A
- Pagella, Pierfrancesco
- Gomes Rodrigues, Helder
- Tsouknidas, Alexander
- Ramenzoni, Liza L
- Radtke, Freddy
- Mehl, Albert
- Viriot, Laurent
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Mitsiadis, T. A., Pagella, P., Gomes Rodrigues, H., Tsouknidas, A., Ramenzoni, L. L., Radtke, F., Mehl, A., & Viriot, L. (2023). Notch Signaling Pathway in Tooth Shape Variations throughout Evolution. Cells, 12(5), 761. https://doi.org/10.3390/cells12050761
