Publication: Increased Metabotropic Glutamate Receptor Subtype 5 Availability in Human Brain After One Night Without Sleep
Increased Metabotropic Glutamate Receptor Subtype 5 Availability in Human Brain After One Night Without Sleep
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Hefti, K., Holst, S. C., Sovago, J., Bachmann, V., Buck, A., Ametamey, S. M., Scheidegger, M., Berthold, T., Gomez-Mancilla, B., Seifritz, E., & Landolt, H.-P. (2013). Increased Metabotropic Glutamate Receptor Subtype 5 Availability in Human Brain After One Night Without Sleep. Biological Psychiatry, 73, 161–168. https://doi.org/10.1016/j.biopsych.2012.07.030
Abstract
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Abstract
BACKGROUND: Sleep deprivation (wake therapy) provides rapid clinical relief in many patients with major depressive disorder (MDD). Changes in glutamatergic neurotransmission may contribute to the antidepressant response, yet the exact underlying mechanisms are unknown. Metabotropic glutamate receptors of subtype 5 (mGluR5) are importantly involved in modulating glutamatergic neurotransmission and neuronal plasticity. The density of these receptors is reduced in the brain of patients with MDD, particularly in brain structures involved
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- Hefti, Katharina
- Holst, Sebastian C
- Sovago, Judit
- Bachmann, Valérie
- Buck, Alfred
- Ametamey, Simon M
- Berthold, Thomas
- Gomez-Mancilla, Baltazar
- Seifritz, Erich
- Landolt, Hans-Peter
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Hefti, K., Holst, S. C., Sovago, J., Bachmann, V., Buck, A., Ametamey, S. M., Scheidegger, M., Berthold, T., Gomez-Mancilla, B., Seifritz, E., & Landolt, H.-P. (2013). Increased Metabotropic Glutamate Receptor Subtype 5 Availability in Human Brain After One Night Without Sleep. Biological Psychiatry, 73, 161–168. https://doi.org/10.1016/j.biopsych.2012.07.030
