Publication: Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold
Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold
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Zhong, S., Kalamatianou, A., Scalese, G., O’Beirne, C., Redrado, M., Blacque, O., Tomasoni, C., Logé, C., Albassier, M., Ourliac-Garnier, I., Pagniez, F., Le Pape, P., Pérez-Díaz, L., Gambino, D., Comini, M. A., Cariou, K., & Gasser, G. (2025). Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold. Inorganic Chemistry, 64(31), 16192–16203. https://doi.org/10.1021/acs.inorgchem.5c02730
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Antimicrobial resistance is a major global problem for public health, indicating the need for the development of new anti-infective drugs, among other actions (i.e., better stewardship, diagnostics, etc.). A common strategy in medicinal chemistry is to modify existing drugs with an organometallic moiety to enhance their efficacy or overcome resistance. One notable example is ferroquine, an organometallic derivative of chloroquine. Here, we describe the design, in-depth characterization, and evaluation of seven new derivatives of the a
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Zhong, S., Kalamatianou, A., Scalese, G., O’Beirne, C., Redrado, M., Blacque, O., Tomasoni, C., Logé, C., Albassier, M., Ourliac-Garnier, I., Pagniez, F., Le Pape, P., Pérez-Díaz, L., Gambino, D., Comini, M. A., Cariou, K., & Gasser, G. (2025). Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold. Inorganic Chemistry, 64(31), 16192–16203. https://doi.org/10.1021/acs.inorgchem.5c02730