Publication: Spatiotemporal organisation of protein processing in the kidney
Spatiotemporal organisation of protein processing in the kidney
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Polesel, M., Kaminska, M., Haenni, D., Bugarski, M., Schuh, C., Jankovic, N., Kaech, A., Mateos, J. M., Berquez, M., & Hall, A. M. (2022). Spatiotemporal organisation of protein processing in the kidney. Nature Communications, 13, 5732. https://doi.org/10.1038/s41467-022-33469-5
Abstract
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Abstract
The kidney regulates plasma protein levels by eliminating them from the circulation. Proteins filtered by glomeruli are endocytosed and degraded in the proximal tubule and defects in this process result in tubular proteinuria, an important clinical biomarker. However, the spatiotemporal organization of renal protein metabolism in vivo was previously unclear. Here, using functional probes and intravital microscopy, we track the fate of filtered proteins in real time in living mice, and map specialized processing to tubular structures w
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- Polesel, Marcello
- Kaminska, Monika
- Haenni, Dominik
- Bugarski, Milica
- Schuh, Claus
- Jankovic, Nevena
- Kaech, Andres
- Berquez, Marine
- Hall, Andrew M
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Polesel, M., Kaminska, M., Haenni, D., Bugarski, M., Schuh, C., Jankovic, N., Kaech, A., Mateos, J. M., Berquez, M., & Hall, A. M. (2022). Spatiotemporal organisation of protein processing in the kidney. Nature Communications, 13, 5732. https://doi.org/10.1038/s41467-022-33469-5
