Publication: Selective Photorelease of an Organometallic-Containing Enzyme Inhibitor
Selective Photorelease of an Organometallic-Containing Enzyme Inhibitor
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Leonidova, A., Mari, C., Aebersold, C., & Gasser, G. (2016). Selective Photorelease of an Organometallic-Containing Enzyme Inhibitor. Organometallics, 35, 851–854. https://doi.org/10.1021/acs.organomet.6b00029
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Histone deacetylases (HDACs) are regarded as promising targets in cancer and a growing number of other diseases due to their crucial involvement in epigenetics and cellular signaling. Many organic HDAC inhibitors are known, and several efficient metal-based analogues have been recently developed. Many of them contain a hydroxamic acid group that binds to the catalytic HDAC zinc center. In this work, a light-activatable organometallic HDAC inhibitor (p-Fc-SAHA) was synthesized and characterized. More specifically, the hydroxamic acid m
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- Leonidova, Anna
- Mari, Cristina
- Aebersold, Christine
- Gasser, Gilles
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Leonidova, A., Mari, C., Aebersold, C., & Gasser, G. (2016). Selective Photorelease of an Organometallic-Containing Enzyme Inhibitor. Organometallics, 35, 851–854. https://doi.org/10.1021/acs.organomet.6b00029