Publication: Synthesis of Some Acyclonucleosides Analogs of 1,4‐Benzothiazine and Their Sulfonates Derivatives: Crystal Structure, Spectroscopic Characterization, DFT Calculations, Hirshfeld Surface Analysis, and Molecular Docking With $Mycobacterium$ $tuberculosis$
Synthesis of Some Acyclonucleosides Analogs of 1,4‐Benzothiazine and Their Sulfonates Derivatives: Crystal Structure, Spectroscopic Characterization, DFT Calculations, Hirshfeld Surface Analysis, and Molecular Docking With $Mycobacterium$ $tuberculosis$
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Irrou, E., Elmachkouri, Y. A., Sert, Y., Blacque, O., Hassan, O., Lhoussaine, E. G., Essassi, E. M., Sebbar, N. K., & Taha, M. L. (2025). Synthesis of Some Acyclonucleosides Analogs of 1,4‐Benzothiazine and Their Sulfonates Derivatives: Crystal Structure, Spectroscopic Characterization, DFT Calculations, Hirshfeld Surface Analysis, and Molecular Docking With $Mycobacterium$ $tuberculosis$. Journal of Heterocyclic Chemistry, 62(5–6), 383–401. https://doi.org/10.1002/jhet.4951
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Ten acyclonucleoside analogs of 1,4‐benzothiazine and their sulfone derivatives (3a,b–8a,b) were synthesized using alkylation reactions under phase‐transfer catalysis (PTC) conditions. The reactions were conducted under optimized conditions, with reaction times ranging from 1.5 to 2 h and yields varying between 70% and 76%. All the synthesized products were characterized using $^{1}$H and $^{13}$C‐NMR spectroscopy. Additionally, the structures of compounds 4a, 6b, 7a, and 8b were confirmed through single‐crystal X‐ray diffraction anal
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Irrou, E., Elmachkouri, Y. A., Sert, Y., Blacque, O., Hassan, O., Lhoussaine, E. G., Essassi, E. M., Sebbar, N. K., & Taha, M. L. (2025). Synthesis of Some Acyclonucleosides Analogs of 1,4‐Benzothiazine and Their Sulfonates Derivatives: Crystal Structure, Spectroscopic Characterization, DFT Calculations, Hirshfeld Surface Analysis, and Molecular Docking With $Mycobacterium$ $tuberculosis$. Journal of Heterocyclic Chemistry, 62(5–6), 383–401. https://doi.org/10.1002/jhet.4951