Publication: RAD51 restricts DNA over-replication from re-activated origins
RAD51 restricts DNA over-replication from re-activated origins
Date
Date
Date
Citations
Muñoz, S., Blanco-Romero, E., González-Acosta, D., Rodriguez-Acebes, S., Megías, D., Lopes, M., & Méndez, J. (2024). RAD51 restricts DNA over-replication from re-activated origins. The EMBO Journal, 43(6), 1043–1064. https://doi.org/10.1038/s44318-024-00038-z
Abstract
Abstract
Abstract
Eukaryotic cells rely on several mechanisms to ensure that the genome is duplicated precisely once in each cell division cycle, preventing DNA over-replication and genomic instability. Most of these mechanisms limit the activity of origin licensing proteins to prevent the reactivation of origins that have already been used. Here, we have investigated whether additional controls restrict the extension of re-replicated DNA in the event of origin re-activation. In a genetic screening in cells forced to re-activate origins, we found that
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Muñoz, Sergio
- Blanco-Romero, Elena
- González-Acosta, Daniel
- Rodriguez-Acebes, Sara
- Megías, Diego
- Lopes, Massimo
- Méndez, Juan
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Publisher DOI
Metrics
Downloads
Views
Citations
Muñoz, S., Blanco-Romero, E., González-Acosta, D., Rodriguez-Acebes, S., Megías, D., Lopes, M., & Méndez, J. (2024). RAD51 restricts DNA over-replication from re-activated origins. The EMBO Journal, 43(6), 1043–1064. https://doi.org/10.1038/s44318-024-00038-z
