Publication: Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display
Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display
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Malhis, M., Kaniyappan, S., Aillaud, I., Chandupatla, R. R., Ramirez, L. M., Zweckstetter, M., Horn, A. H. C., Mandelkow, E., Sticht, H., & Funke, S. A. (2021). Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display. Chembiochem, 22(21), 3049–3059. https://doi.org/10.1002/cbic.202100287
Abstract
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Abstract
Alzheimer's disease and other Tauopathies are associated with neurofibrillary tangles composed of Tau protein, as well as toxic Tau oligomers. Therefore, inhibitors of pathological Tau aggregation are potentially useful candidates for future therapies targeting Tauopathies. Two hexapeptides within Tau, designated PHF6* (275-VQIINK-280) and PHF6 (306-VQIVYK-311), are known to promote Tau aggregation. Recently, the PHF6* segment has been described as the more potent driver of Tau aggregation. We therefore employed mirror-image phage dis
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- Malhis, Marwa
- Kaniyappan, Senthilvelrajan
- Aillaud, Isabelle
- Chandupatla, Ram Reddy
- Ramirez, Lisa Marie
- Zweckstetter, Markus
- Horn, Anselm H C
- Mandelkow, Eckhard
- Sticht, Heinrich
- Funke, Susanne Aileen
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Malhis, M., Kaniyappan, S., Aillaud, I., Chandupatla, R. R., Ramirez, L. M., Zweckstetter, M., Horn, A. H. C., Mandelkow, E., Sticht, H., & Funke, S. A. (2021). Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display. Chembiochem, 22(21), 3049–3059. https://doi.org/10.1002/cbic.202100287
