Publication: Brief communication: identification of the authentic ancient DNA sequence in a human bone contaminated with modern DNA
Brief communication: identification of the authentic ancient DNA sequence in a human bone contaminated with modern DNA
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Bouwman, A. S., Chilvers, E. R., Brown, K. A., & Brown, T. A. (2006). Brief communication: identification of the authentic ancient DNA sequence in a human bone contaminated with modern DNA. American Journal of Physical Anthropology, 131(3), 428–431. https://doi.org/10.1002/ajpa.20411
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We present a method to distinguish authentic ancient DNA from contaminating DNA in a human bone. This is achieved by taking account of the spatial distribution of the various sequence families within the bone and the extent of degradation of the template DNAs, as revealed by the error content of the sequences. To demonstrate the veracity of the method, we handled two ancient human tibiae in order to contaminate them with modern DNA, and then subjected segments of the bones to various decontaminating treatments, including removal of th
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- Bouwman, Abigail S
- Chilvers, Elizabeth R
- Brown, Keri A
- Brown, Terence A
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Bouwman, A. S., Chilvers, E. R., Brown, K. A., & Brown, T. A. (2006). Brief communication: identification of the authentic ancient DNA sequence in a human bone contaminated with modern DNA. American Journal of Physical Anthropology, 131(3), 428–431. https://doi.org/10.1002/ajpa.20411